Pueraria Mirifica Extract

Pueraria Mirifica Extract INQUIRE

General description:

Botanical name Pueraria mirifica
Family Papilionaceae
Common Name Kwao Krua, Thai Kudzu
Part used Root

Pueraria mirifica root has been used in Thailand for more than 700 years. Legend has touted the anti-aging properties of this plant for centuries. The plants are abundant in the forests in the north, the west and the northeast of Thailand at the altitude of 300-800 meters above sea level. Active principles in this plant are found in the tuberous root, which looks like a chain of round-shaped bulbs of various sizes connected to the next one via small root throughout the entire length of the root. Folklore goes on to say that the root is a "fountain of youth" for aged men and women. It helps to smooth wrinkled skin, supports healthy hair growth, improves eye health, sharpens the memory, increases energy and vigor, improves appetite and supports restful sleep.

Chemical constituents:

P.mirifica contains estrogen-like compounds, including genistein and daidzein. Scientific studies elucidated chemical components in Pueraria, including phytoestrogens which are more potent than those found in soy, such as miroestrol and deoxymiroestrol. These natural agents function like estrogen in the body.[1] Its tuberous root contains phytoestrogens, isoflavones (daidzin, daidzein, genistin, genistein, and puerarin) and miroestrol and its derivatives, β-sitosterol, stigmasterol, coumestrol, puerarin, mirificoumestan, kwakhurin, and mirificin.[2]

Pharmacological activities:

P. mirifica is being used as an alternative medicine for the estrogen effect in humans. Many commercial products in the form of cream, tablet, and solution are available from P. mirifica roots.It is not only used by women, but also became popular in men as an age rejuvenation drug. P. mirifica plays an expensive role in helping to maintain a healthy hormone balance in menopausal women, when estrogen levels drop, and women experience changes in mood, hot flashes, lower libido, sleep interruption and other health issues. Pueraria has been featured in products that help support breast firmness, as well as protecting breast tissue. It has a high level of antioxidant activity, probably due to their ability to increase the cell protective substance called superoxide dismutase (SOD).[1] Reports about the effect of P. mirifica on reproductive organs are available. Alcoholic extract of P. mirifica stimulated the proliferation of vaginal and uterus epithelium in female rats and women.[3] P. mirifica contained phytoestrogens that behave as an estrogen in inducing vaginal cornification in ovariectomized rats.[4] It also inhibited the follicular growth and ovulation in female rats. Single dose of P. mirifica prolonged the menstrual cycle length in adult cyclic cynomolgus monkeys. Clinical trial showed that P. mirifica clearly reduced the menopausal symptoms in women.[2] A double-blind study was conducted on 52 hysterectomized women with menopausal symptoms who had an indication for hormone therapy. The women were randomly allocated into two groups receiving either P. mirifica 25 mg (n = 26) or P. mirifica 50 mg tablet (n = 26) for 6 months. Both dosages were similarly effective and safe in the treatment of menopausal symptoms.[5] In another study 19 postmenopausal women were randomly assigned to receive oral administration of P. mirifica powder or placebo. After 2 months of the treatment, P. mirifica treated group showed a significant increase in serum concentrations of high-density lipoprotein (HDL) cholesterol and a decrease in low-density lipoprotein (LDL). Study concluded that P. mirifica has a beneficial effect on lipid metabolism in postmenopausal women.[6]

Genistein Daidzein Miroestrol

Safety:

Pueraria is proved to be safe due to it's long history of safe use, along with modern scientific data that supports its safety and efficacy. Safety studies show that the normal therapeutic dose provides a wide margin of safety. Mutagenic study confirmed its non-mutagenesis which supports current use as safe dietary supplements and cosmetics of P. mirifica.[7]

References:

  1. Arora A et al. 1998. Antioxidant activities of isoflavones and their biological metabolites in a liposomal system. Arc Biochem Biophys. 356:133-141
  2. Malaivijitnond et al. 2004. Different effects of Pueraria mirifica, a herb containing phytoestrogens, on LH and FSH secretion in gonadectomized female and male rats. J Pharmacol Sci. 96:428 – 435
  3. Sukavattana T. 1940. Oestrogenic principle of Butea superba, preliminary report. J Med Assoc Thai. 24:183–194.
  4. Pope et al., 1958. The estrogenic substance (miroestrol) from the tuberous roots of P. mirifica. J Endocrinol. 17:15–16.
  5. Virojchaiwong et al., 2011. Comparison of Pueraria mirifica 25 and 50 mg for menopausal symptoms. Arch Gynecol Obstet. 284(2):411-9.
  6. Okamura et al., 2008. Pueraria mirifica phytoestrogens improve dyslipidemia in postmenopausal women probably by activating estrogen receptor subtypes. Tohoku J Exp Med. 216(4):341-51.
  7. Cherdshewasart et al., 2009. The mutagenic and antimutagenic effects of the traditional phytoestrogen-rich herbs, Pueraria mirifica and Pueraria lobata. Braz J Med Biol Res. 42(9):816-23.

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